Migration by haptotaxis of a Schwann cell tumor line to the basement membrane glycoprotein laminin

@article{McCarthy1983MigrationBH,
  title={Migration by haptotaxis of a Schwann cell tumor line to the basement membrane glycoprotein laminin},
  author={James B. McCarthy and Sally L. Palm and Leo T. Furcht},
  journal={The Journal of Cell Biology},
  year={1983},
  volume={97},
  pages={772 - 777}
}
Laminin is a large (greater than 850-kdalton) glycoprotein that is localized within basement membranes. Recent work has indicated that this protein is present within the endoneurium of mouse sciatic nerve. Furthermore, it has been shown that a rat Schwannoma cell line, RN22F, produced laminin and that laminin promoted the attachment of these cells to bacterial plastic. This report presents evidence that RN22F cells migrate in vitro to laminin in a concentration-dependent fashion. Laminin was… CONTINUE READING