Migration and invasion of oral squamous carcinoma cells is promoted by WNT5A, a regulator of cancer progression.

  title={Migration and invasion of oral squamous carcinoma cells is promoted by WNT5A, a regulator of cancer progression.},
  author={Zdenka Prgomet and Lena Axelsson and Pia Lindberg and Tommy Andersson},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  volume={44 10},
BACKGROUND Oral squamous cell carcinoma (OSCC) constitutes 90% of all cancers in the oral cavity, and the prognosis for patients diagnosed with OSCC is still poor. The identification of novel therapeutic targets and prognostic markers for OSCC is therefore essential. Previous studies of OSCC revealed an increased expression of WNT5A in the tumor tissue. However, no functional studies of WNT5A-induced effects in OSCC have been performed. METHODS Two different OSCC cell lines were used for… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 37 references

A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 10 Excerpts
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N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration.

The Journal of biological chemistry • 2013
View 6 Excerpts
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EMT, the cytoskeleton, and cancer cell invasion

Cancer and Metastasis Reviews • 2008
View 1 Excerpt
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