Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods

  title={Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods},
  author={Joseph Altman and Shirley A. Bayer},
  journal={Journal of Comparative Neurology},
Methacrylate‐embedded sections and short‐survival thymidine radiograms of the hippocampal dentate gyrus were examined in perinatal and postnatal rats in order to trace the site of origin and migration of the precursors of granule cells and study the morphogenesis of the granular layer. The densely packed, spindle‐shaped cells of the secondary dentate matrix (a derivative of the primary dentate neuroepithelium) stream in a subpial position towards the granular layer of the internal dentate limb… 

Development of astroglial cells in the proliferative matrices, the granule cell layer, and the hippocampal fissure of the hamster dentate gyrus

These findings indicate that the dentate matrices not only produce neurons of the stratum granulosum, but also provide a separate population of “secondary” radial glial cells which organizes the glio‐neuronal aggregation of the primordial granule cell layer.

Distinctive population of Gfap‐expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus

Results suggest that distinctive Gfap‐expressing progenitors arising around the dentate notch form germinal regions in the migratory stream and the developing dentate gyrus where they differentiate into granule neurons, indicating that distinct astrocyte‐like neural progenitor continue to generate granule neuron, from the beginning of dentate development and throughout life.

Unique Expression Patterns of Cell Fate Molecules Delineate Sequential Stages of Dentate Gyrus Development

It is established that the expression patterns of bHLH mRNAs evolve during the formation of the dentate gyrus, and the precursor cells resident in the mature dentate Gyrus share features with precursor cells found in development.

Differential Postnatal Expression of Neuronal Maturation Markers in the Dentate Gyrus of Mice and Rats

The results suggest that the first month of postnatal development represents an important transition phase during which DG Neurogenesis and the maturation course of the GC population becomes analogous to the process of adult neurogenesis, and could serve as an attractive model for studying a growing and functionally maturing neural network.

Development of microglia in the postnatal rat hippocampus

In both Ammon's horn and the dentate gyrus, cells resembling reactive microglia are also observed and, in particular, in the perforant path projections from P9 to P18, suggesting their participation not only in phagocytosis of dead cells but also in axonal elimination and/or fiber reorganization.

Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus

It is demonstrated that the expression of brain lipid‐binding protein, GLAST, and glial fibrillary acidic protein (GFAP) characterizes immature differentiating cells confined to an astrocytic fate in the early postnatal dentate gyrus.

Translocation of Synaptically Connected Interneurons across the Dentate Gyrus of the Early Postnatal Rat Hippocampus

Immunostaining with anti-glial fibrillary acidic protein and three-dimensional reconstructions from serial EM images indicate that, unlike granule cells, which migrate from the hilus to the granular layer, interneurons traverse this layer in the opposite direction without apparent surface-mediated guidance of the radial glial cells.

A Distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis

It is confirmed that the outside‐in layering of the dentate gyrus continues through adulthood and that early‐born cells constitute most of the adult dentate Gyrus, and that a subpopulation of hippocampal progenitors divides infrequently from early development onward.

The development of the radial glial scaffold of the cerebellar cortex from GFAP-positive cells in the external granular layer

The results suggest that the majority of the Golgi epithelial cells are not translocated, morphologically transformed primordial radial glia cells, but derive from the external granular layer, translocate into the Purkinje cell layer and differentiate into the secondary radial glial cells which intercalate with the basal processes of primordialrad glia.

Postnatal cellular contributions of the hippocampus subventricular zone to the dentate gyrus, corpus callosum, fimbria, and cerebral cortex

It is suggested that the early postnatal HSVZ progenitors are multipotent and migratory, and contribute to both dentate gyrus neurogenesis as well as forebrain gliogenesis.



Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

It is postulated that undifferentiated cells migrate postnatally from the forebrain ventricles to the hippocampus where they become differentiated, implicating that they may function as receptors of gonadal hormones.

Subgranular zone of the dentate gyrus of young rabbits as a secondary matrix. A high-resolution autoradiographic study.

It is concluded that the subgranular zone functions as a secondary matrix for granule neurons of the dentate gyrus in young rabbits, and may be recruited during the development and refinement of postnatal behavioral substrates, by one or other of the dominant afferent systems.

Radial organization of the hippocampal dentate gyrus: A Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey

The present results indicate that the developing dentate gyrus in primates consists of a series of ontogenetic radial units that resemble those described in the fetal neocortex (Rakic, '72), and suggest that the development and maintenance of this radial columnar organization may be imposed by the orientation of glial scaffolding during development.

Prolonged sojourn of developing pyramidal cells in the intermediate zone of the hippocampus and their settling in the stratum pyramidale

In radiograms of rat embryos that received a single dose of [3H] thymidine between days E16 and E20 and were killed 24 hours after the injection, the heavily labeled cells form a horizontal layer in the intermediate zone of the hippocampus, called the inferior band.

Postnatal Development of the Hippocampal Dentate Gyrus Under Normal and Experimental Conditions

The authors do not as yet have an adequate explanation of the delayed formation of microneurons but the importance of these elements in the maturation of brain functions is indicated by behavioral studies.

Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cells

The results indicate that the hippocampal neuroepithelium consists of three morphogenetically discrete components—the Ammonic neuroepIthelium, the primary dentate neuroepIThelium and the fimbrial glioepit Helium—and that these are discrete sources of the large neurons of Ammon's horn, the smaller granular neurons of the dentate gyrus, and the glial cells of thefimbria.

Development of the hippocampal region in the rat I. Neurogenesis examined with 3H‐thymidine autoradiography

  • S. Bayer
  • Biology
    The Journal of comparative neurology
  • 1980
Neurogenesis in the rat hippocampal region was examined with 3H‐thymidine autoradiography and the percentage of labelled cells and the proportion of cells added during each day of formation were determined at several anatomical levels.

Autoradiographic investigation of cell proliferation in the brains of rats and cats

The results indicate that glia cells can multiply in the brains of young adult rats and adult cats and they support the possibility that new neurons may be formed in forebrain structures, both in rodents and carnivores.