Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain

@article{Tabar2005MigrationAD,
  title={Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain},
  author={Viviane S Tabar and Georgia Panagiotakos and Edward D Greenberg and Bill K Chan and Michel Sadelain and Philip H. Gutin and Lorenz P Studer},
  journal={Nature Biotechnology},
  year={2005},
  volume={23},
  pages={601-606}
}
Human embryonic stem (hES) cells provide a potentially unlimited cell source for regenerative medicine. Recently, differentiation strategies were developed to direct hES cells towards neural fates in vitro. However, the interaction of hES cell progeny with the adult brain environment remains unexplored. Here we report that hES cell–derived neural precursors differentiate into neurons, astrocytes and oligodendrocytes in the normal and lesioned brain of young adult rats and migrate extensively… CONTINUE READING
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