Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis.

@article{Joy2003MigratingGC,
  title={Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis.},
  author={Anna M. Joy and Christian Beaudry and Nhan L. Tran and Francisco Ponce and David Holz and T. Demuth and Michael E. Berens},
  journal={Journal of cell science},
  year={2003},
  volume={116 Pt 21},
  pages={4409-17}
}
Glioma cells that migrate out of the main tumor mass into normal brain tissue contribute to the failure of most gliomas to respond to treatment. Treatments that target migratory glioma cells may enhance the therapeutic response. Multiple lines of evidence suggest that suppression of apoptosis accompanies activation of the migratory phenotype. Here, we determine whether migration and apoptosis are consistently linked in glioma cells and whether manipulation of migration influences cytotoxic… CONTINUE READING