Migraine pain, meningeal inflammation, and mast cells

@article{Levy2009MigrainePM,
  title={Migraine pain, meningeal inflammation, and mast cells},
  author={Dan Levy},
  journal={Current Pain and Headache Reports},
  year={2009},
  volume={13},
  pages={237-240}
}
  • D. Levy
  • Published 10 May 2009
  • Medicine
  • Current Pain and Headache Reports
Migraine pain has been attributed to an episode of local sterile meningeal inflammation and the subsequent activation of trigeminal primary afferent nociceptive neurons that supply the intracranial meninges and their related large blood vessels. However, the origin of this inflammatory insult and the endogenous factors that contribute to the activation of meningeal nociceptors remain largely speculative. A particular class of inflammatory cells residing within the intracranial milieu, known as… 
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Intracranial headaches such as migraine are thought to result from activation of sensory trigeminal pain neurons that supply intracranial blood vessels and the meninges, also known as meningeal
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TLDR
The activity of primary afferent neurons in the rat trigeminal ganglion that innervate the dural venous sinuses are recorded, showing properties of meningeal afferents that may contribute to the intracranial mechanical hypersensitivity that is characteristic of some types of clinically occurring headaches, and to the throbbing pain of migraine.
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TLDR
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