Migraine genetics

  title={Migraine genetics},
  author={Pasquale Montagna},
  journal={Expert Review of Neurotherapeutics},
  pages={1321 - 1330}
  • P. Montagna
  • Published 1 September 2008
  • Psychology, Biology
  • Expert Review of Neurotherapeutics
Migraine with aura (MA) and migraine without aura (MO) are primary headaches prevalent in the general population that carry a substantial familial liability. Based on the model of migraine as a complex disease, a multifactorial type of inheritance has been suggested, but familial hemiplegic migraine (FHM), classified as a subtype of MA, shows an autosomal dominant transmission pattern and is due to mutations in three genes encoding for neural channel subunits. These FHM mutations, however… 

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