Migraine association and linkage analyses of the human 5-hydroxytryptamine (5HT2A) receptor gene.

@article{Nyholt1996MigraineAA,
  title={Migraine association and linkage analyses of the human 5-hydroxytryptamine (5HT2A) receptor gene.},
  author={Dale R. Nyholt and Robert P. Curtain and P T Gaffney and Peter J. Brimage and Peter J Goadsby and Lyn R Griffiths},
  journal={Cephalalgia : an international journal of headache},
  year={1996},
  volume={16 7},
  pages={463-7}
}
5-Hydroxytryptamine (5HT), commonly known as serotonin, which predominantly serves as an inhibitory neurotransmitter in the brain, has long been implicated in migraine pathophysiology. This study tested an MspI polymorphism in the human 5HT2A receptor gene (HTR2A) and a closely linked microsatellite marker (D13S126), for linkage and association with common migraine. In the association analyses, no significant differences were found between the migraine and control populations for both the MspI… CONTINUE READING