Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules

@article{Berti2003Mig12AN,
  title={Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules},
  author={Caterina Berti and B. Fontanella and Rosa Ferrentino and Germana Meroni},
  journal={BMC Cell Biology},
  year={2003},
  volume={5},
  pages={9 - 9}
}
Opitz G/BBB syndrome is a genetic disorder characterized by developmental midline abnormalities, such as hypertelorism, cleft palate, and hypospadias. The gene responsible for the X-linked form of this disease, MID1, encodes a TRIM/RBCC protein that is anchored to the microtubules. The association of Mid1 with the cytoskeleton is regulated by dynamic phosphorylation, through the interaction with the α4 subunit of phosphatase 2A (PP2A). Mid1 acts as an E3 ubiquitin ligase, regulating PP2A… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Xlinked Opitz syndrome: novel mutations in the MID1 gene and redefinition of the clinical spectrum

  • F De Falco, S Cainarca, +14 authors G Meroni
  • Am J Med Genet 2003,
  • 2003
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…