Mig and IP‐10: CXC chemokines that target lymphocytes

@article{Farber1997MigAI,
  title={Mig and IP‐10: CXC chemokines that target lymphocytes},
  author={Joshua M Farber},
  journal={Journal of Leukocyte Biology},
  year={1997},
  volume={61}
}
  • J. Farber
  • Published 1 March 1997
  • Biology, Medicine
  • Journal of Leukocyte Biology
Mig and IP‐10 are related members of the CXC subfamily of the chemokine family of cytokines. The murine Mig (MuMig), human IP‐10, and the mouse homologue of IP‐10, Crg‐2, were all identified due to the dramatic inductions of their genes in monocytic cells treated with interferon‐γ (IFN‐γ). Studies using recombinant (r) human proteins show that, unlike most other CXC chemokines, rHuMig and rIP‐10 have no activity on neutrophils but appear to target lymphocytes specifically. rHuMig and rIP‐10 are… Expand
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