Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation.

Abstract

PTEN mutations are the most common genetic alterations in endometrial cancer. Loss of PTEN and subsequent AKT activation stimulate estrogen receptor α-dependent pathways that play an important role in endometrial tumorigenesis. The major pathologic phenomenon of endometrial cancer is the loss of ovarian steroid hormone control over uterine epithelial cell… (More)
DOI: 10.1158/0008-5472.CAN-14-0794

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