Mifepristone pretreatment reduces ethanol withdrawal severity in vivo.

  title={Mifepristone pretreatment reduces ethanol withdrawal severity in vivo.},
  author={L. Sharrett-Field and T. Butler and J. N. Berry and A. Reynolds and M. Prendergast},
  journal={Alcoholism, clinical and experimental research},
  volume={37 8},
  • L. Sharrett-Field, T. Butler, +2 authors M. Prendergast
  • Published 2013
  • Psychology, Medicine
  • Alcoholism, clinical and experimental research
  • BACKGROUND Prolonged ethanol (EtOH) intake may perturb function of the hypothalamic-pituitary-adrenal axis in a manner that promotes dependence and influences EtOH withdrawal severity. Prior in vivo and in vitro studies suggest that corticosteroids, in particular, may be elevated during EtOH intoxication and withdrawal, suggesting that intracellular glucocorticoid receptors (GRs) may promote the development of EtOH dependence. METHODS Adult male Sprague-Dawley rats were subjected to a 4-day… CONTINUE READING
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    Induction of physical dependence upon ethanol and the associated behavioral changes in rats
    • 687
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    • 683
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