Mifepristone in the Central Nucleus of the Amygdala Reduces Yohimbine Stress-Induced Reinstatement of Ethanol-Seeking

@article{Simms2012MifepristoneIT,
  title={Mifepristone in the Central Nucleus of the Amygdala Reduces Yohimbine Stress-Induced Reinstatement of Ethanol-Seeking},
  author={Jeffrey A. Simms and Carolina L Haass-Koffler and Jade J. Bito-Onon and Rui Li and Selena E Bartlett},
  journal={Neuropsychopharmacology},
  year={2012},
  volume={37},
  pages={906-918}
}
Chronic ethanol exposure leads to dysregulation of the hypothalamic-pituitary-adrenal axis, leading to changes in glucocorticoid release and function that have been proposed to maintain pathological alcohol consumption and increase vulnerability to relapse during abstinence. The objective of this study was to determine whether mifepristone, a glucocorticoid receptor antagonist, plays a role in ethanol self-administration and reinstatement. Male, Long–Evans rats were trained to self-administer… CONTINUE READING
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