Mifepristone With Buccal Misoprostol for Medical Abortion: A Systematic Review

@article{Chen2015MifepristoneWB,
  title={Mifepristone With Buccal Misoprostol for Medical Abortion: A Systematic Review},
  author={Melissa J. Chen and Mitchell D. Creinin},
  journal={Obstetrics \& Gynecology},
  year={2015},
  volume={126},
  pages={12–21}
}
OBJECTIVE: To summarize clinical outcomes and adverse effects of medical abortion regimens consisting of mifepristone followed by buccal misoprostol in pregnancies through 70 days of gestation. DATA SOURCES: We used PubMed, ClinicalTrials.gov, and reference lists from published reports to identify relevant studies published between November 2005 and January 2015 using the search terms “mifepristone and medical abortion” and “buccal and misoprostol.” METHODS OF STUDY SELECTION: Studies were… 
Mifepristone With Buccal Misoprostol for Medical Abortion: A Systematic Review.
TLDR
The review authors indicate that the data from 332 patients identified between 64 and 70 days of gestation offer insufficient evidence to recommend clinical use, yet this sample provides a confidence interval of 89.6–95.5 in which even the lower limit represents a highly efficacious procedure that women should be allowed to choose.
Efficacy of Misoprostol Alone for First-Trimester Medical Abortion: A Systematic Review.
TLDR
Misoprostol alone is effective and safe and is a reasonable option for women seeking abortion in the first trimester, and research is indicated to further refine the regimen and to establish efficacy in the late firsttrimester.
Outcomes During Early Implementation of Mifepristone-Buccal Misoprostol Abortions up to 63 Days of Gestation in a Canadian Clinical Setting.
Pain during medical abortion: a multicenter study in France.
Outpatient medical abortion is safe and effective through 70 days gestation.
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References

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Efficacy and safety of mifepristone and buccal misoprostol versus buccal misoprostol alone for medical abortion
TLDR
Though the efficacy of mifepristone followed by buCCal misoprostol is better, buccal misOProstol alone can be used for termination of pregnancy in patients where mifEPristone is either unavailable or contraindicated.
Two Distinct Oral Routes of Misoprostol in Mifepristone Medical Abortion: A Randomized Controlled Trial
TLDR
Buccal misoprostol 800 mcg after mifepristone 200 mg is a good option for medical abortion through 63 days since the last menstrual period, although success rates diminish with increasing gestational age.
Comparing two early medical abortion regimens: mifepristone+misoprostol vs. misoprostol alone.
Mifepristone followed by home administration of buccal misoprostol for medical abortion up to 70 days of amenorrhoea in a general practice in Curaçao
TLDR
Home administration of buccal misoprostol 24–36 h after mifepristone is a safe and effective method of medical abortion up to 70 days, and could be applied in a general practice in Curaçao, where induced abortion is legally restricted.
Extending Outpatient Medical Abortion Services Through 70 Days of Gestational Age
TLDR
Medical abortion with mifepristone and misoprostol in current outpatient settings is an efficacious and acceptable method of ending pregnancies 64–70 days from LMP and can be offered without alteration of existing services.
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