Mifepristone-Misoprostol Use for Second and Third Trimester Medical Termination of Pregnancy in a Canadian Tertiary Care Centre.

@article{Vlad2022MifepristoneMisoprostolUF,
  title={Mifepristone-Misoprostol Use for Second and Third Trimester Medical Termination of Pregnancy in a Canadian Tertiary Care Centre.},
  author={Sergiu Vlad and Isabelle Boucoiran and {\'E}milie Roy St-Pierre and Ema Ferreira},
  journal={Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC},
  year={2022}
}
  • Sergiu VladI. Boucoiran E. Ferreira
  • Published 31 January 2022
  • Medicine
  • Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Labour induction for termination of pregnancy with severe fetal anomalies after 24 weeks’ gestation: a case series and systematic review of the literature

The case series illustrates successful termination of pregnancy primarily using combined mifepristone-misoprostol, and certainty of current evidence is low, based on the GRADE framework.

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Services offering home administration of mifepristone as pretreatment could optimize efficacy and acceptability of medical abortions for women with gestations 14–21 weeks since the last menstrual period.

Induction of delivery by mifepristone and misoprostol in termination of pregnancy and intrauterine fetal death: 2nd and 3rd trimester induction of labour

The objective of this pilot was to describe the effectiveness of combined mifepristone–misoprostol regimen for labour induction in ToP and IUFD.

Mifepristone and Misoprostol vs Misoprostol Alone in Second Trimester Termination of Pregnancy

Mifepristone and misoprostol combined together is now an established, highly effective and safe method for medical method of second trimester termination, although a higher total dose is needed and side effects are higher than with the combined regimen.

A Comparative Study of Misoprostol Only and Mifepristone Plus Misoprostol in Second Trimester Termination of Pregnancy

Pretreatment with mifepristone significantly reduces the induction abortion interval and the misoprostol dose along with minimal blood loss.

Influence of Mifepristone in Induction Time for Terminations in the Second and Third Trimester.

The induction intervals between initial administration of prostaglandin and delivery can be significantly shortened by the prior administration of mifepristone, which is the most effective regimen for the medical termination of pregnancy.

Mifepristone in Second-Trimester Medical Abortion: A Randomized Controlled Trial

Addition of mifepristone in second-trimester termination inductions using misoprostol significantly reduces the abortion time interval.

Medical termination for pregnancy in early first trimester (≤ 63 days) using combination of mifepristone and misoprostol or misoprostol alone: a systematic review

Combined regimens using mifepristone and misoprostol had lower rates of ongoing pregnancy, higher rates of successful abortion and satisfaction compared to misOProstol only regimens and the rate of serious adverse events was generally low.