Mifepristone (RU-486) treatment for depression and psychosis: a review of the therapeutic implications

@article{Gallagher2006MifepristoneT,
  title={Mifepristone (RU-486) treatment for depression and psychosis: a review of the therapeutic implications},
  author={Peter Gallagher and Allan Hunter Young},
  journal={Neuropsychiatric Disease and Treatment},
  year={2006},
  volume={2},
  pages={33 - 42}
}
The mechanisms underlying the pathophysiology of severe psychiatric illnesses are complex, involving multiple neuronal and neurochemical pathways. A growing body of evidence indicates that alterations in hypothalamic-pituitary-adrenal (HPA) axis function may be a trait marker in both mood disorders and psychosis, and may exert significant causal and exacerbating effects on symptoms and neurocognition. At present, however, no available treatments preferentially target HPA axis abnormalities… CONTINUE READING
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