Midregion parathyroid hormone-related protein inhibits growth and invasion in vitro and tumorigenesis in vivo of human breast cancer cells.

@article{Luparello2001MidregionPH,
  title={Midregion parathyroid hormone-related protein inhibits growth and invasion in vitro and tumorigenesis in vivo of human breast cancer cells.},
  author={Claudio Luparello and R Romanotto and Annalisa Tipa and Rosalia Sirchia and Nieves Olmo and Isabel L{\'o}pez de Silanes and Javier Turnay and Mar{\'i}a Antonia Lizarbe and Andrew Francis Stewart},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2001},
  volume={16 12},
  pages={
          2173-81
        }
}
Parathyroid hormone-related protein (PTHrP) is critical for normal mammary development and is overexpressed by breast cancers. PTHrP is a peptide hormone that undergoes extensive post-translational processing, and PTHrP(38-94)-amide is one of the mature secretory forms of the peptide. In this study, we explored the effect of PTHrP(38-94)-amide in a panel of six breast cancer cell lines "in vitro" and in MDA-MB231 cells "in vivo" specifically examining cell viability, proliferation, invasiveness… CONTINUE READING
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