Midodrine. A review of its therapeutic use in the management of orthostatic hypotension.

@article{Mcclellan1998MidodrineAR,
  title={Midodrine. A review of its therapeutic use in the management of orthostatic hypotension.},
  author={K. J. Mcclellan and Lynda R. Wiseman and Michelle I. Wilde},
  journal={Drugs & aging},
  year={1998},
  volume={12 1},
  pages={
          76-86
        }
}
Midodrine is a prodrug which undergoes enzymatic hydrolysis to the selective alpha 1-adrenoceptor agonist desglymidodrine after oral administration. Oral midodrine significantly increases 1-minute standing systolic blood pressure compared with placebo. The drug also improves standing time and energy level and clinical symptoms of orthostatic hypotension including dizziness, light-headedness and syncope. Comparative studies have shown midodrine to have similar efficacy to dihydroergotamine… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

The Role of Midodrine for Hypotension Outside of the Intensive Care Unit.

  • Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique
  • 2017
VIEW 8 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Autonomic neuropathy : treatment

VIEW 1 EXCERPT
CITES BACKGROUND