Midodrine and Clonidine in Patients With Cirrhosis and Refractory or Recurrent Ascites: A Randomized Pilot Study

@article{Singh2013MidodrineAC,
  title={Midodrine and Clonidine in Patients With Cirrhosis and Refractory or Recurrent Ascites: A Randomized Pilot Study},
  author={Virendra Singh and Ajay Singh and Baljinder Singh and Rajesh Vijayvergiya and Navneet Sharma and Anchal Ghai and Ashish Bhalla},
  journal={The American Journal of Gastroenterology},
  year={2013},
  volume={108},
  pages={560-567}
}
OBJECTIVES:Splanchnic arterial vasodilatation and subsequent activation of anti-natriuretic and vasoconstrictive mechanisms have an important role in cirrhotic ascites. The aim of this study was to evaluate the effects of midodrine, clonidine, and their combination on systemic hemodynamics, renal function, and control of ascites in patients with cirrhosis and refractory or recurrent ascites.METHODS:Sixty cirrhotic patients with refractory or recurrent ascites were prospectively studied after… CONTINUE READING