Midline governs axon pathfinding by coordinating expression of two major guidance systems.

@article{Liu2009MidlineGA,
  title={Midline governs axon pathfinding by coordinating expression of two major guidance systems.},
  author={Qingxin Liu and Masaki Hiramoto and Hitoshi Ueda and Takashi Gojobori and Yasushi Hiromi and Susumu Hirose},
  journal={Genes & development},
  year={2009},
  volume={23 10},
  pages={1165-70}
}
Formation of the neural network requires concerted action of multiple axon guidance systems. How neurons orchestrate expression of multiple guidance genes is poorly understood. Here, we show that Drosophila T-box protein Midline controls expression of genes encoding components of two major guidance systems: Frazzled, ROBO, and Slit. In midline mutant, expression of all these molecules are reduced, resulting in severe axon guidance defects, whereas misexpression of Midline induces their… CONTINUE READING

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