Midlife memory improvement predicts preservation of hippocampal volume in old age.

@article{Borghesani2012MidlifeMI,
  title={Midlife memory improvement predicts preservation of hippocampal volume in old age.},
  author={Paul R Borghesani and Kurt E. Weaver and Elizabeth H. Aylward and Anne Richards and Tara M. Madhyastha and Ali R Kahn and Olivia Liang and Rachel L Ellenbogen and Mirza Faisal Beg and K. Warner Schaie and Sherry L. Willis},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 7},
  pages={1148-55}
}
This study examines whether midlife change in episodic memory predicts hippocampal volume in old age. From the Seattle Longitudinal Study we retrospectively identified 84 healthy, cognitively normal individuals, age 52 to 87, whose episodic memory had reliably declined (n = 33), improved (n = 28) or remained stable (n = 23) over a 14-year period in midlife (age 43-63). Midlife memory improvement was associated with 13% larger hippocampal volume (p < 0.01) in old age (age 66-87), compared with… CONTINUE READING