Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study.

@article{Petrovitch2000MidlifeBP,
  title={Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study.},
  author={Helen Petrovitch and Lon R. White and G Izmirilian and George Webster Ross and Richard J. Havlik and William R. Markesbery and James S. Nelson and Daron G. Davis and John A. Hardman and Daniel J. Foley and Lenore J. Launer},
  journal={Neurobiology of aging},
  year={2000},
  volume={21 1},
  pages={57-62}
}
Midlife hypertension is associated with later development of cognitive impairment, vascular dementia (VsD), and possibly Alzheimer's disease (AD). Neuropathic cerebrovascular lesions and brain atrophy have been associated with elevated blood pressure (BP), however, to our knowledge there have been no prospective investigations of an association of blood pressure levels measured in midlife with the microscopic lesions of AD. We investigated the relationship of BP level in midlife to development… CONTINUE READING
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