Midlife adiposity predicts earlier onset of Alzheimer’s dementia, neuropathology and presymptomatic cerebral amyloid accumulation

@article{Chuang2016MidlifeAP,
  title={Midlife adiposity predicts earlier onset of Alzheimer’s dementia, neuropathology and presymptomatic cerebral amyloid accumulation},
  author={Y-F Chuang and Yang Soo An and Murat Bilgel and Dean F. Wong and Juan C Troncoso and Richard J. O'Brien and John C. S. Breitner and Luigi Ferruci and Susan M. Resnick and Madhav Thambisetty},
  journal={Molecular Psychiatry},
  year={2016},
  volume={21},
  pages={910-915}
}
Understanding how midlife risk factors influence age at onset (AAO) of Alzheimer’s disease (AD) may provide clues to delay disease expression. Although midlife adiposity predicts increased incidence of AD, it is unclear whether it affects AAO and severity of Alzheimer’s neuropathology. Using a prospective population-based cohort, Baltimore Longitudinal Study of Aging (BLSA), this study aims to examine the relationships between midlife body mass index (BMI) and (1) AAO of AD (2) severity of… CONTINUE READING
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