Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease: The Atherosclerosis Risk in Communities Study.

@article{Walker2017MidlifeSI,
  title={Midlife Systemic Inflammation, Late-Life White Matter Integrity, and Cerebral Small Vessel Disease: The Atherosclerosis Risk in Communities Study.},
  author={Keenan A. Walker and Melinda Carolyn Power and Ron C. Hoogeveen and Aaron R Folsom and Christie M. Ballantyne and David S. Knopman and Beverly Gwen Windham and Elizabeth Selvin and Clifford R. Jack and Rebecca F. Gottesman},
  journal={Stroke},
  year={2017},
  volume={48 12},
  pages={
          3196-3202
        }
}
BACKGROUND AND PURPOSE It is currently unclear whether midlife systemic inflammation promotes the development of white matter (WM) abnormalities and small vessel disease in the elderly. We examined the association of midlife systemic inflammation with late-life WM hyperintensity volume, deep and periventricular WM microstructural integrity (fractional anisotropy and mean diffusivity [MD]), cerebral infarcts, and microbleeds in a biracial prospective cohort study. METHODS Linear and logistic… CONTINUE READING