Midkine regulates pleiotrophin organ-specific gene expression: evidence for transcriptional regulation and functional redundancy within the pleiotrophin/midkine developmental gene family.

@article{Herradn2005MidkineRP,
  title={Midkine regulates pleiotrophin organ-specific gene expression: evidence for transcriptional regulation and functional redundancy within the pleiotrophin/midkine developmental gene family.},
  author={Gonzalo Herrad{\'o}n and Laura Ezquerra and Trang Thi Nhu Nguyen and Inmaculada Silos-Santiago and Thomas F. Deuel},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={333 3},
  pages={714-21}
}
Midkine (MK) and the highly related cytokine pleiotrophin (PTN) constitute the PTN/MK developmental gene family. The Mk and Ptn genes are essential for normal development of the catecholamine and renin-angiotensin pathways and the synthesis of different collagens. It is not known whether the Ptn and Mk genes regulate each other or whether PTN and MK are functionally redundant in development. We have now compared the levels of expression of Ptn and Mk in genetically deficient Mk -/- and Ptn… CONTINUE READING