Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy

@article{Kosugi2007MidkineII,
  title={Midkine is involved in tubulointerstitial inflammation associated with diabetic nephropathy},
  author={Tomoki Kosugi and Yukio Yuzawa and Waichi Sato and Hanayo Arata-Kawai and Norihiko Suzuki and Noritoshi Kato and Seiichi Matsuo and Kenji Kadomatsu},
  journal={Laboratory Investigation},
  year={2007},
  volume={87},
  pages={903-913}
}
The concept that inflammation plays a crucial role in the pathogenesis of diabetic nephropathy has been recently emerging, although the principal pathology of diabetic nephropathy comprises glomerular sclerosis and associated changes in nephrons. Here, we identified the growth factor midkine (MK) as a novel key molecule involved in inflammation associated with Streptozotocin-induced diabetic nephropathy. The tubulointerstitial damage, as assessed as morphological changes, osteopontin expression… CONTINUE READING