Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction.

  title={Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction.},
  author={Arihiro Sumida and Mitsuru Horiba and Hisaaki Ishiguro and Hiroharu Takenaka and Norihiro Ueda and Hiroaki Ooboshi and Tobias Opthof and Kenji Kadomatsu and Itsuo Kodama},
  journal={Cardiovascular research},
  volume={86 1},
AIM We have previously reported that therapy with midkine (MK) has a protective effect in mouse models of myocardial infarction (MI) and ischemia/reperfusion. The underlying mechanism was proved to be anti-apoptosis and prevention of left ventricular (LV) remodelling following angiogenesis. Here we investigated the effects of overexpression of MK by adenoviral gene transfer on cardiac function and remodelling in an experimental rat MI model. METHODS AND RESULTS MI was created in male Wistar… 

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