Midkine expression in transient retinal ischemia in the rat.

  title={Midkine expression in transient retinal ischemia in the rat.},
  author={Miki Miyashiro and Kenji Kadomatsu and Nahoko Ogata and Chikako Yamamoto and Kanji Takahashi and Masanobu Uyama and Hisako Muramatsu and T. Ohdaira M. Muramatsu},
  journal={Current eye research},
  volume={17 1},
PURPOSE Midkine (MK), a 13-kDa heparin-binding growth factor, is known to exert neurotrophic activities on various nerve cells including retinal cells. To initiate studies toward determining the physiological role of endogenous MK, we investigated the spatial and temporal expression profile of MK before and after intraocular pressure-induced retinal ischemia. METHODS Retinal ischemia was induced in Wistar strain rats by increasing the intraocular pressure to 110 mm Hg for 45 min via… CONTINUE READING