Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading.

  title={Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading.},
  author={Astrid Liedert and Laura Mattausch and Viktoria R{\"o}ntgen and Robert Blakytny and Daniel Vogele and Marcus Pahl and Ronny Bindl and Claudia Neunaber and Thorsten Schinke and Sheila Harroch and Michael Amling and Anita Ignatius},
  volume={48 4},
The adaptive response of bone to load is dependent on molecular factors, including growth factor signaling, which is involved in the regulation of proliferation, differentiation and function of osteoblasts and osteoclasts. Based on a recent study, which has shown that the deficiency of growth factor midkine (Mdk) in mice at 12 and 18 months of age resulted in increased trabecular bone formation, we hypothesized that mechanically-induced bone remodeling may, at least in part, be dependent on Mdk… CONTINUE READING
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