Middle interhemispheric variant of holoprosencephaly associated with diffuse polymicrogyria.

@article{Takanashi2003MiddleIV,
  title={Middle interhemispheric variant of holoprosencephaly associated with diffuse polymicrogyria.},
  author={Jun-Ichi Takanashi and A. James Barkovich and Nancy J. Clegg and Mauricio R. Delgado},
  journal={AJNR. American journal of neuroradiology},
  year={2003},
  volume={24 3},
  pages={394-7}
}
An 11-month-old boy was discovered to have a cleft palate, club foot, hypospadias, and myoclonic seizures. No in utero exposure to teratogens was identified. Brain MR imaging revealed a middle interhemispheric fusion variant of holoprosencephaly, diffuse polymicrogyria, and a hypoplastic brain stem; this was a distinctly unusual association of findings. We hypothesize that an unknown genetic factor causes disturbances of cleavage of the prosencephalon as well as neuronal migration and… CONTINUE READING
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