Middle interhemispheric variant of holoprosencephaly: a distinct cliniconeuroradiologic subtype.

@article{Lewis2002MiddleIV,
  title={Middle interhemispheric variant of holoprosencephaly: a distinct cliniconeuroradiologic subtype.},
  author={Angela Lewis and Erin M. Simon and A. James Barkovich and Nancy J. Clegg and Mauricio R. Delgado and Eric B. Levey and Jin S. Hahn},
  journal={Neurology},
  year={2002},
  volume={59 12},
  pages={1860-5}
}
BACKGROUND The middle interhemispheric variant (MIH) is a subtype of holoprosencephaly (HPE) in which the posterior frontal and parietal areas lack midline separation, whereas more polar areas of the cerebrum are fully cleaved. While the neuroradiologic features of this subtype have been recently detailed, the clinical features are largely unknown. OBJECTIVE To present the clinical manifestations of MIH and to compare them with classic subtypes (alobar, semilobar, and lobar) of HPE. METHODS… CONTINUE READING
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