Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.

@article{Siu2014MiddleER,
  title={Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.},
  author={Kitty Siu and Man Lung Yeung and Kin-Hang Kok and Kit-san Yuen and Chun Kew and Pak-Yin Lui and Chi-ping Chan and Herman Tse and Patrick C. Y. Woo and Kwok-Yung Yuen and Dong-Yan Jin},
  journal={Journal of virology},
  year={2014},
  volume={88 9},
  pages={
          4866-76
        }
}
UNLABELLED Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging pathogen that causes severe disease in human. MERS-CoV is closely related to bat coronaviruses HKU4 and HKU5. Evasion of the innate antiviral response might contribute significantly to MERS-CoV pathogenesis, but the mechanism is poorly understood. In this study, we characterized MERS-CoV 4a protein as a novel immunosuppressive factor that antagonizes type I interferon production. MERS-CoV 4a protein contains a… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 51 CITATIONS

FILTER CITATIONS BY YEAR

2014
2019

CITATION STATISTICS

  • 3 Highly Influenced Citations

  • Averaged 9 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

Cytosolic sensing of 561 viruses. Immunity 38:855-869

  • D Goubau, S Deddouche, C. Reis e Sousa
  • 2013
Highly Influential
6 Excerpts

Isolation of a novel coronavirus from a man with pneumonia in Saudi 464 Arabia

  • AM Zaki, S van Boheemen, TM Bestebroer, AD Osterhaus, RA. Fouchier
  • N. Engl. J. Med
  • 2012
Highly Influential
7 Excerpts

Genomic characterization of a newly discovered coronavirus associated 461 with acute respiratory distress syndrome in humans

  • S van Boheemen, M de Graaf, +8 authors RA. Fouchier
  • MBio 3:e00473-12
  • 2012
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…