Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model.

  title={Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model.},
  author={Ludmila Belayev and Ofelia Furones Alonso and Raul Busto and W. Zhao and Myron D. Ginsberg},
  volume={27 9},
          1616-22; discussion 1623
BACKGROUND AND PURPOSE The purpose of the present study was to evaluate a modified method of intraluminal suture occlusion of the middle cerebral artery (MCA) on the volume of brain infarction and on neurobehavioral function in rats subjected to a temporary focal ischemic insult. METHODS Male Sprague-Dawley rats were anesthetized with halothane and subjected to 60 minutes or 2 hours of temporary MCA occlusion (MCAo) by an intraluminal thread. In one group of rats, the suture was coated with… 

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