Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications.

@article{Vgontzas2001MiddleagedMS,
  title={Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications.},
  author={Alexandros N. Vgontzas and Edward O. Bixler and A M Wittman and Keith Zachman and H M Lin and Antonio Vela-Bueno and Anthony Kales and George P. Chrousos},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 4},
  pages={1489-95}
}
The prevalence of insomnia associated with emotional stress increases markedly in middle-age. Both the top and end hormones of the hypothalamic-pituitary-adrenal axis, i.e. CRH and glucocorticoids, stimulate arousal/wakefulness and inhibit slow wave (deep) sleep in experimental animals and man. The objective of this study was to test the hypothesis that middle-age is characterized by increased sensitivity to the sleep-disturbing effects of the hypothalamic-pituitary-adrenal axis. We studied 12… CONTINUE READING

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