Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

@article{Bour2008MiddleagedHA,
  title={Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks},
  author={Alexandra Bour and Jeannette Grootendorst and Elise Vogel and Christian Kelche and Chantal Mathis},
  journal={Behavioural Brain Research},
  year={2008},
  volume={193},
  pages={174-182}
}
Apolipoprotein (apo) E4, one of three human apoE (h-apoE) isoforms, has been identified as a major genetic risk factor for Alzheimer's disease and for cognitive deficits associated with aging. However, the biological mechanisms involving apoE in learning and memory processes are unclear. A potential isoform-dependent role of apoE in cognitive processes was studied in human apoE targeted-replacement (TR) mice. These mice express either the human apoE3 or apoE4 gene under the control of… CONTINUE READING

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