Middle age aggravates myocardial ischemia through surprising upholding of complex II activity, oxidative stress, and reduced coronary perfusion

@article{Mourmoura2010MiddleAA,
  title={Middle age aggravates myocardial ischemia through surprising upholding of complex II activity, oxidative stress, and reduced coronary perfusion},
  author={Evangelia Mourmoura and Marie Leguen and Herv{\'e} Dubouchaud and Karine Couturier and Damien Vitiello and Jean-Luc Lafond and Melanie Richardson and Xavier Leverve and Luc Demaison},
  journal={AGE},
  year={2010},
  volume={33},
  pages={321-336}
}
Aging compromises restoration of the cardiac mechanical function during reperfusion. We hypothesized that this was due to an ampler release of mitochondrial reactive oxygen species (ROS). This study aimed at characterising ex vivo the mitochondrial ROS release during reperfusion in isolated perfused hearts of middle-aged rats. Causes and consequences on myocardial function of the observed changes were then evaluated. The hearts of rats aged 10- or 52-week old were subjected to global ischemia… CONTINUE READING