Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.

@article{Niemeyer2013MiddleER,
  title={Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist.},
  author={Daniela Niemeyer and Thomas Zillinger and Doreen Muth and Florian Zielecki and G{\'a}bor Andr{\'a}s Horv{\'a}th and Tasnim Suliman and Winfried Barchet and Friedemann Weber and Christian Drosten and Marcel A M{\"u}ller},
  journal={Journal of virology},
  year={2013},
  volume={87 22},
  pages={12489-95}
}
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory infection with as yet unclear epidemiology. We previously showed that MERS-CoV counteracts parts of the innate immune response in human bronchiolar cells. Here we analyzed accessory proteins 3, 4a, 4b, and 5 for their abilities to inhibit the type I interferon response. Accessory protein 4a was found to block interferon induction at the level of melanoma differentiation-associated protein 5 (MDA5) activation… CONTINUE READING
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