Midbrain dopaminergic neurons are protected from radical induced damage by GDF-5 application

@article{Lingor1999MidbrainDN,
  title={Midbrain dopaminergic neurons are protected from radical induced damage by GDF-5 application},
  author={Paul Lingor and Klaus Unsicker and Kerstin Krieglstein},
  journal={Journal of Neural Transmission},
  year={1999},
  volume={106},
  pages={139-144}
}
Embryonic day 14 rat midbrain cultures were kept for 7 days in vitro and then intoxicated with radical donors iron and sodium-nitroprusside for 24 h. Tyrosine-hydroxylase positive neurons in cultures which were additionally treated with growth/differentiation factor-5 (GDF-5) survived to a significantly higher percentage as compared to sister cultures without factor supplementation. Since the degeneration of TH positive cells is a key feature in Parkinson's disease, GDF-5 might be a putative… CONTINUE READING

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1995a) TGF-â superfamily

  • K Krieglstein, C Suter-Crazzolara, WH Fischer, K Unsicker
  • 1995
Highly Influential
7 Excerpts

MPP1 toxicity

  • K Krieglstein, C Suter-Crazzolara, G Hotten, J Pohl, K Unsicker
  • EMBO J
  • 1995
Highly Influential
7 Excerpts

Neuronal death due to apoptosis

  • B Faucheux, E Hirsch, Y Agid
  • 1997

Neuronal death due to apoptosis in Parkinson ’ s disease

  • M Ruberg, V France-Lanord, +7 authors Y Agid
  • Rev Neurol
  • 1997
1 Excerpt

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