Midbrain development induced by FGF8 in the chick embryo

Abstract

VERTEBRATE midbrain development depends on an organizing centre located at the isthmus, a constriction in the embryonic mid/hindbrain region1–3,28. Isthmic tissue grafts transform chick caudal forebrain into an ectopic midbrain that is the mirror image of the normal midbrain4. Here we report that FGF8 protein has the same midbrain-inducing and polarizing… (More)
DOI: 10.1038/380066a0

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