Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55.

@article{Lee2008MidbodyTO,
  title={Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55.},
  author={Hyung Ho Lee and Natalie Elia and Rodolfo Ghirlando and Jennifer Lippincott-Schwartz and James H. Hurley},
  journal={Science},
  year={2008},
  volume={322 5901},
  pages={576-80}
}
The ESCRT (endosomal sorting complex required for transport) machinery is required for the scission of membrane necks in processes including the budding of HIV-1 and cytokinesis. An essential step in cytokinesis is recruitment of the ESCRT-I complex and the ESCRT-associated protein ALIX to the midbody (the structure that tethers two daughter cells) by the protein CEP55. Biochemical experiments show that peptides from ALIX and the ESCRT-I subunit TSG101 compete for binding to the ESCRT and ALIX… CONTINUE READING
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