Midazolam premedication delays recovery after propofol without modifying involuntary movements.

@article{Bevan1997MidazolamPD,
  title={Midazolam premedication delays recovery after propofol without modifying involuntary movements.},
  author={Joan C Bevan and G R Veall and Andrew J. Macnab and Craig R. Ries and Cheryl Marsland},
  journal={Anesthesia and analgesia},
  year={1997},
  volume={85 1},
  pages={50-4}
}
Midazolam has GABAergic effects in children that may modify propofol-induced involuntary movements, yet delay recovery. In a double-blind, randomized study, 24 children (2-7 yr of age, ASA physical status I or II) undergoing short surgical procedures received midazolam 0.5 mg/kg (Group M) or placebo (Group P) per os 20-30 min before propofol anesthesia (5 mg/kg intravenously followed by an infusion). Blind observers scored sedation and anxiety levels (scale 1-4) before premedication, at… CONTINUE READING

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