Midazolam inhibits long-term potentiation through modulation of GABAA receptors.

@article{Evans1996MidazolamIL,
  title={Midazolam inhibits long-term potentiation through modulation of GABAA receptors.},
  author={M. Steven Evans and K E Viola-McCabe},
  journal={Neuropharmacology},
  year={1996},
  volume={35 3},
  pages={347-57}
}
Benzodiazepine drugs (BZ) are used for anxiety, insomnia, and seizures. They worsen memory, especially in large doses, but the mechanism of this action is uncertain. In micromolar concentrations, benzodiazepines have been shown to reduce long-term potentiation (LTP), which could be a cellular basis for their amnesic action. We have found that the LTP-inhibiting effects of BZ occur in the nanomolar concentrations attained in humans, and that this effect occurs through modulation of GABAA… CONTINUE READING
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