Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae.

@article{Rajavel1999Mid2IA,
  title={Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae.},
  author={M Rajavel and Bevin Philip and Benjamin M. Buehrer and Beverly Errede and David E. Levin},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 6},
  pages={3969-76}
}
Hcs77 is a putative cell surface sensor for cell integrity signaling in Saccharomyces cerevisiae. Its loss of function results in cell lysis during growth at elevated temperatures (e.g., 39 degrees C) and impaired signaling to the Mpk1 mitogen-activated protein kinase in response to mild heat shock. We isolated the MID2 gene as a dosage suppressor of the cell lysis defect of an hcs77 null mutant. MID2 encodes a putative membrane protein whose function is required for survival of pheromone… CONTINUE READING
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