Microwave-promoted syntheses of quinazolines and dihydroquinazolines from 2-aminoarylalkanone O-phenyl oximes.

@article{PortelaCubillo2009MicrowavepromotedSO,
  title={Microwave-promoted syntheses of quinazolines and dihydroquinazolines from 2-aminoarylalkanone O-phenyl oximes.},
  author={Fernando Portela-Cubillo and Jackie S. Scott and John C Walton},
  journal={The Journal of organic chemistry},
  year={2009},
  volume={74 14},
  pages={
          4934-42
        }
}
A wide range of biologically active compounds contain the quinazoline ring system. A new free-radical-based method of making functionalized quinazolines is described, which relies on microwave-promoted reactions of O-phenyl oximes with aldehydes. A small set of 2-aminoaryl alkanone O-phenyl oximes was prepared and shown to produce dihydroquinazolines when mixed with an aldehyde in toluene and subjected to microwave heating. When ZnCl(2) was included in the reaction mixture, fully aromatic… CONTINUE READING
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