Microwave-assisted synthesis of the anticancer drug cisplatin, cis-[Pt(NH3)2Cl2].

Abstract

A microwave-assisted synthesis of cisplatin, cis-[Pt(NH3)2Cl2], has been developed and optimized on both a 0.2 and 0.05 millimolar scale. The optimized synthetic procedure was modeled after the Lebedinskii-Golovnya method and is suitable for incorporating the radionuclide, (195m)Pt, into cisplatin for biological studies. Highest yields (47%) and purity are… (More)
DOI: 10.1039/c4dt03617d

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