Microwave-assisted green synthesis of new imidazo[2,1-b]thiazole derivatives and their antimicrobial, antimalarial, and antitubercular activities

  title={Microwave-assisted green synthesis of new imidazo[2,1-b]thiazole derivatives and their antimicrobial, antimalarial, and antitubercular activities},
  author={Rajesh H. Vekariya and Kinjal D. Patel and Mayur K. Vekariya and Neelam P. Prajapati and Dhanji P. Rajani and Smita D. Rajani and Hitesh D. Patel},
  journal={Research on Chemical Intermediates},
We have synthesized some imidazo[2,1-b]thiazole derivatives by reaction of 1-(2-amino-4-methylthiazol-5-yl)ethanone or ethyl 2-amino-4-methylthiazole-5-carboxylate with α-bromo aralkyl ketones (phenacyl bromides) in presence of polyethylene glycol-400 (PEG-400) as efficient, inexpensive, biodegradable, and green reaction medium and catalyst (dual nature) under Microwave Irradiation (MWI) at 300 W as well as under thermal heating at 90 °C. Moreover, we also synthesized 1-(2-amino-4-methylthiazol… 
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