Microwave-assisted green synthesis of new imidazo[2,1-b]thiazole derivatives and their antimicrobial, antimalarial, and antitubercular activities

@article{Vekariya2017MicrowaveassistedGS,
  title={Microwave-assisted green synthesis of new imidazo[2,1-b]thiazole derivatives and their antimicrobial, antimalarial, and antitubercular activities},
  author={Rajesh H. Vekariya and Kinjal D. Patel and Mayur K. Vekariya and Neelam P. Prajapati and Dhanji P. Rajani and Smita D. Rajani and Hitesh D. Patel},
  journal={Research on Chemical Intermediates},
  year={2017},
  volume={43},
  pages={6207-6231}
}
We have synthesized some imidazo[2,1-b]thiazole derivatives by reaction of 1-(2-amino-4-methylthiazol-5-yl)ethanone or ethyl 2-amino-4-methylthiazole-5-carboxylate with α-bromo aralkyl ketones (phenacyl bromides) in presence of polyethylene glycol-400 (PEG-400) as efficient, inexpensive, biodegradable, and green reaction medium and catalyst (dual nature) under Microwave Irradiation (MWI) at 300 W as well as under thermal heating at 90 °C. Moreover, we also synthesized 1-(2-amino-4-methylthiazol… 
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All the tested compounds had exhibited good anti-proliferative efficacy against hepatic cancer cell lines and may act as promising candidates as drugs against hepatocellular carcinoma.
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Metal-free efficient thiolation of C(sp2) functionalization via in situ-generated NHTS for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole
A direct metal-free approach for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole derivatives at room temperature is reported via an in situ-generated electrophilic thiolating…
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7-chloroquinoline-piperazine derivatives exhibited potential antimalarial compounds for pf-DHFR inhibitors, and in-vitro studies of synthesized molecules showed that compounds C2, C6, C10, and C14 possess good antimalaria activity.
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The review summarizes and analyzes literature data on the methods of synthesis and biological properties of known types of imidazothiazoles. The classification of existing synthetic methods is based…
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This review is primarily addressed to the description of the recent advances in the synthesis of heterocyclic compounds as anthelmintic agents, which can facilitate the development of more potent and effective anthel mintic agents.
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