Microwave and magnetic (M(2) ) proteomics of the experimental autoimmune encephalomyelitis animal model of multiple sclerosis.

@article{Raphael2012MicrowaveAM,
  title={Microwave and magnetic (M(2) ) proteomics of the experimental autoimmune encephalomyelitis animal model of multiple sclerosis.},
  author={Itay Raphael and Swetha Mahesula and Karan Kalsaria and Venkat Kotagiri and Anjali B. Purkar and M. Anjanappa and Darshit Shah and Vidya C Pericherla and Yeshwant Lal Avinash Jadhav and Rekha Raghunathan and Michael Vaynberg and D C Noriega and Nazul H Grimaldo and Carola Wenk and Jonathan A. Gelfond and Thomas G. Forsthuber and William E. Haskins},
  journal={Electrophoresis},
  year={2012},
  volume={33 24},
  pages={
          3810-9
        }
}
We hypothesized that quantitative MS/MS-based proteomics at multiple time points, incorporating rapid microwave and magnetic (M(2) ) sample preparation, could enable relative protein expression to be correlated to disease progression in the experimental autoimmune encephalomyelitis (EAE) animal model of multiple sclerosis. To test our hypothesis, microwave-assisted reduction/alkylation/digestion of proteins from brain tissue lysates bound to C8 magnetic beads and microwave-assisted isobaric… CONTINUE READING
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