Microwave-Assisted Regioselective Synthesis of 3-Functionalized Indole Derivatives via Three-Component Domino Reaction.

@article{Lin2017MicrowaveAssistedRS,
  title={Microwave-Assisted Regioselective Synthesis of 3-Functionalized Indole Derivatives via Three-Component Domino Reaction.},
  author={Wei gang Lin and Yong-Xiang Zheng and Zhan Xun and Zhi-bin Huang and Da-Qing Shi},
  journal={ACS combinatorial science},
  year={2017},
  volume={19 11},
  pages={
          708-713
        }
}
A microwave-assisted regioselective synthesis of 3-functionalized indole derivatives via a three-component domino reaction of anilines, arylglyoxal monohydrates, and cyclic 1,3-dicarbonyl compounds is described. The main advantages of this protocol are short reaction times, practical simplicity, its metal-free nature, the availability of starting materials, green solvents, and high regioselectivity. 

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