Microwave-Assisted Direct Thioesterification of Carboxylic Acids.

  title={Microwave-Assisted Direct Thioesterification of Carboxylic Acids.},
  author={Yen-Lin Chou and Yi Jhong and Sharada Prasanna Swain and Duen-Ren Hou},
  journal={The Journal of organic chemistry},
  volume={82 19},
A one-pot synthesis of thioesters directly from carboxylic acids, N,N'-diphenylthiourea, triethylamine, and primary alkyl halides is described. Microwave-assisted heating and a catalytic amount of 4-(dimethylamino)pyridine (DMAP) further improved the yields. Both aromatic and aliphatic carboxylic acids were converted to the corresponding thioesters, and… CONTINUE READING