Microvillar membrane microdomains exist at physiological temperature. Role of galectin-4 as lipid raft stabilizer revealed by "superrafts".

@article{Braccia2003MicrovillarMM,
  title={Microvillar membrane microdomains exist at physiological temperature. Role of galectin-4 as lipid raft stabilizer revealed by "superrafts".},
  author={Anita Braccia and Maristella Villani and Lissi Immerdal and Lise-Lotte Niels-Christiansen and Birthe T Nystr\om and Gert Helge Hansen and Erik Danielsen},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 18},
  pages={15679-84}
}
Lipid rafts (glycosphingolipid/cholesterol-enriched membrane microdomains) have been isolated as low temperature, detergent-resistant membranes from many cell types, but despite their presumed importance as lateral sorting and signaling platforms, fundamental questions persist concerning raft function and even existence in vivo. The nonionic detergent Brij 98 was used to isolate lipid rafts from microvillar membrane vesicles of intestinal brush borders at physiological temperature to compare… CONTINUE READING
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